In the sensitization process, efferent outputs that involve connections between motor neurons and neural nociceptive afferents occur, which in turn generate motor responses [74,75].
In the sensitization as well as in the elicitation phase, DCs derived from Cytip KO mice induced an increased inflammatory reaction indicated by more pronounced ear swelling.
Beta-blockers have significant cardiovascular effects and their chronic use results in the sensitization of β-ARs, rendering these receptors more sensitive to agonists.
It is not clear from available reports whether Stard4 plays any direct role in the allergic response, however, the microarray and real-time RT-PCR data from all antigen sensitized groups in our study demonstrates its involvement in the sensitization of food allergens.
Comparison of the differentially expressed genes in BLG, OVA and PNA sensitized groups implicates that a common set of genes involved in the sensitization phase of the immune response to these three food allergens in BALB/c mice.
Although further experiments are necessary to clarify this issue, there are several potential mechanisms, whereby endogenous P2X7 could participate in the sensitization of the trigeminovascular system.
The aim of this in vitro study was to determine the potential use of these analogues in the sensitization of various cancer cells to gamma radiation.
Three different grain sizes (150 μm, 40 μm, and 15 μm) were uniaxially deformed to 10%and20%0% strain, and aged in the sensitization ranges of 625°C and 775°C.
The abrogation of the crucial ROS signaling was confirmed with RNP treatment, which deterred ROS-regulated drug efflux protein (P-gp and MRP1) expression, resulting in the sensitization of resistant cells to Dox.
However, the laser-surface-melted specimens became much more susceptible to IGC in the sensitization temperature region, and the corrosion rate of the resensitized specimen was even higher than that of the base materials under the same sensitization condition.
In addition, emotional factors, such as depression or anxiety, and poor sleep quality can also play a role in the sensitization process by increasing excitability of the nociceptive firing [7, 8].
