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Polymorphisms of the dopamine receptor 4 (DRD4) gene are implicated in the predisposition to episodic migraine attacks but not in drug abuse [33].
Our results indicate two IBD loci and further support the importance of the innate immune system in the predisposition to both CD and UC.
"They raise new questions about the earliest brain changes involved in the predisposition to Alzheimer's and the extent to which they could be targeted by future prevention therapies".
The present findings suggest that the three studied polymorphisms within the TREM-1 gene may not play a major role in the predisposition to severe sepsis in a Chinese Han cohort.
This dissimilarity may bear consequences either in the predisposition to deletions occurring within the D4Z4 repeat array or in the structural consequences of the deletion.
This difference may bear consequences either in the predisposition to deletions occurring within the D4Z4 repeat array or in the pathological consequences thereof.
The importance of specific allelic polymorphisms in the predisposition of human beings to longevity or resistance to age-related disorders has been emphasized by studies of centenarians [3].
As mentioned above, two recent GWA studies [7], [8] suggested the role of the CNS in the predisposition to the non-syndromic form of obesity.
Instead, there are changes in the predisposition of the cellular populations to senescence, and perhaps to growth stimuli and transforming events.
However, this association could not be replicated in an independent set of 81 smaller families (173 nuclear families, Set II) also originating from France, indicating that different genetic factors may be involved in the predisposition to psoriasis in our population.
Both of the GWA studies hypothesized a role of the central nervous system (CNS) in the predisposition to a common form of obesity as has previously been shown for rare monogenic forms of obesity.
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