Based on a 5-point scoring scale for the detection of lesions, more lesions (>50%) were considered true lesions in the later scans (5 to 7 days after each infusion) than in scans performed earlier (Figures 5 and 6).
For the connective tissues underlying the epithelia (e.g., lamina propria), a limited increase was discerned, from around 1500 HU in earlier scans (A and B) to around 1500 2000 HU in the later scans (C and D).
In addition, the later scan (180 min after injection) could provide more accurate prediction of chemoresistance than early scan (30 min after injection) [ 47].
In Patient 3, lesion 9 began with an intact BM, but in later scans, the BM appeared to be disrupted, suggesting that in the initial stages, the pathological process was localized above the choroid, and only after disruption of the BM, it progressed into the choroid.
Therefore, some of the lesions in other studies may have been rated as negative in later scans, although the lesion might have been positive in early scans.
Based on the increased lesion visualization in later scans compared to earlier time points, the optimal time for lesion detection, and therefore imaging, appears to be 5 to 7 days.
In Patient 8, the rapidly progressive nature of this cystic leukoencephalopathy was further catalogued on imaging at 7, 8 and 11 months of age as shown in later scans in Fig. 1F and I.
The high correlation between the two sequential MR studies suggests that in infants with moderate or severe HIE treated with hypothermia, conventional and diffusion MR images performed around the fourth day of life can accurately depict hypoxic-ischemic lesions seen in later scans performed during the second week of life.
For feathers and skin in the cervical region, that had already reached a high CT value (3000 3500 HU) during earlier scans (A and B), the peak value did not significantly change in later scans C and D (Fig. 5e: a).
Therefore, their peak CT value did not significantly change in later scans C and D, compared to the earlier scans (Figs. 1, 3, 5).
Or alternatively, does it show that the brain area is involved in carrying out the task, but that it becomes more efficient with practice, and so shows less activity in later scans?
