Moreover, the extended study in [18] was considering optimization of multiple objectives to improve driving efficiency.
Although it is not possible to plan for all contingencies, awareness of potential pitfalls may help to avoid some of the factors that contributed to the extended study duration in these programmes.
In the current extended study, in the prednisolone group, the treatment with nasal steroids maintained the improvement reached with oral steroids, while in the placebo group, both subjective and objective outcomes showed improvement over time with the nasal steroid treatment.
In the extended report of the FAME study, there was a considerably higher incidence of cataract surgery in phakic eyes in the 0.2 and 0.5 µg/day fluocinolone groups (80%andd 87.2% compared with 27.3%) and increased IOP at any point (37% and 46% compared with 12%).
Moreover, another randomized, placebo-controlled, double-blind study was conducted two years later over 12 months by Calverley et al. In this extended study, an improvement of the postbronchodilator FEV-1 by roflumilast was also reported [29].
In the present extended study, performed from 2010 to 2012, patients included in the follow-up had undergone surgery at least 5 years previously.
Duration of study treatment period varied from as little as 12 weeks in many studies to 12 months in a few, or in the more extended studies up to 2 years for a few patients [ 8, 9, 17, 20, 21] (Additional File 3).
Land use was mapped in greater detail in the extended Bovanenkovo study area (Figure 4).
In the extended case study, the researcher deals with qualitative data, but also considers the broader complex social situation.
We acknowledge Raj Kishore Pasam and Dr. Benjamin Kilian (IPK Gatersleben, Germany) for his help and support in the extended LD study.
