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Exogenous juvenile hormones (JH) application at this time maintains the larval secretory program, resulting in supernumerary (extra) instars.
Prolonged treatment of MCPH1 patient lymphoblastoid cell lines with nocodazole results in supernumerary centrosomes, a feature also observed in Seckel syndrome [13].
PROS GoF induces proliferation arrest and PROS LoF results in supernumerary cells with sustained expression of cell cycle markers, indicating an inability to withdraw from the cell cycle.
The possible primary role of Fgf signalling in supernumerary tooth formation in Lrp4 mutants can be excluded since no changes in Sprouty expression or Fgf signalling were observed (data not shown), suggesting that the Bmp/Shh interaction lies downstream of Fgf signalling.
It was present in supernumerary copes in Δ3/KH39, which grew without any losses.
It was then assessed whether the increase in supernumerary centrosomes was due to fragmentation or overduplication of centrosomes.
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In addition, supernumerary centrosomes were found in PARP-1 deficient cells [ 25].
Ontology analysis in the supernumerary chromosome 31 showed that this chromosome is enriched in genes involved in iron metabolism and other related molecular functions (Table 3, Additional file 1: Table S4).
However, practice principals were mixed in opinion about the financial cost involved in this supernumerary supervisor model.
All four enzymes purified in the presence of n-dodecyl-β D-maltoside had a complete complement of core subunits involved directly in the synthesis of ATP, but they were deficient to different extents in their supernumerary membrane subunits.
With the installation of Emperor Alexander I of Russia in 1813, supernumerary membership was extended to foreign monarchs, who are known as "Stranger Knights and Ladies of the Garter".
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