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Discover Ludwig"in significance" is correct and can be used in written English.
It is usually used to indicate that something is important or significant in some way. For example: "The changes in policy had, in significance, a positive effect on the lives of those affected."
Exact(59)
Railroads rank third in significance.
"All other issues paled in significance".
Bit of a gulf in significance there.
The extract from her poem Equinox is rich in significance.
Your sibling's bronze swimming certificates must pale in significance.
So this match and this tournament are wreathed in significance.
Vuillard's virtue was to paint small pictures wildly out of proportion in significance to their size.
Nuclear power plants rival thermal plants in significance.
He said Saturday that common-law suits are limited "both in significance and number".
The history of strip cartoons!' As a result, novels expand in size but shrink in significance.
Tricolons are a rhetorical flourish – a sonorous list of three concepts, often escalating in significance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com