However, similar to other chronic diseases, there is no «gold» standard for the diagnosis of RA. 1 4 The 1987 American College of Rheumatology (ACR) RA classification criteria, while very specific in patients with established RA, are limited in their sensitivity to identify early disease stages.
For example, questionnaires may differ in their sensitivity to identify cases where respondents consider their symptoms trivial.
The discrepancy may arise from difference in pathophysiology of the diseases and is further explained by increased ability and thus sensitivity to identify nNOS in specific locations using histochemistry and immunohistochemistry methods of detection as used in the present study.
A diagnostic algorithm developed to distinguish influenza from dengue using rash, leukopenia, and marked thrombocytopenia showed >90% sensitivity to identify influenza in pediatric patients.
Relying on the added value of sequencing matched tumor and germline DNA and using a dedicated analysis, UDT-Seq has a high sensitivity to identify mutations in tumors with low malignant cell content.
17, 18 The recently developed FLOTAC technique, which is also based on microscopic detection of helminth eggs in stool samples, has a higher sensitivity to identify light soil-transmitted helminth infections, and the application is gaining popularity in research studies conducted across the world.
One strategy to address heterogeneity in sensitivity to obatoclax is to identify and examine pharmacodynamic (PD) markers that can be retro- or prospectively correlated with response in clinical trials.
Known and novel genes whose loss of function confers alterations in sensitivity to the camptothecins can be identified.
In this study, we explored the spatial variability in sensitivity to heat in Brisbane and identified area-level risk factors associated with the spatial patterns in risk.
To date, no miRNA which represses TYMS expression leading to an increase in sensitivity to 5-FU has been identified.
