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In contrast, HDAC inhibition has been shown to result in sensitisation to TRAIL-R1 specific apoptosis [ 48, 56].
It has been implicated in sensitisation to chemotherapy and as a prognostic marker in several common cancers.
Thus, cleavage of Bid is involved in sensitisation to TRAIL of colorectal (Lacour et al, 2001; Ravi and Bedi, 2002) and prostate cancer cells (Nimmanapalli et al, 2001).
The statistically significant differences between the arms were mainly in sensitisation to cow's milk and hen's egg proteins at 6 months.
An initial study by Giaever et al (1999) demonstrated that yeast strains with heterozygous deletion of drug targets can result in sensitisation to the drug target of interest in comparison with the diploid strain (haploinsufficiency profiling).
It was of interest, therefore, to determine whether a higher dose of UCN-01 (300 n M) for a shorter treatment period (24 h) (a protocol described previously (Wang et al, 1996)), would be more effective at abrogation of the G2 checkpoint and would result in sensitisation to IR-induced cell death in the S/RG/C2 cell line which was not previously sensitised.
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There is evidence that allergic sensitisation can begin in infancy, in particular sensitisation to food allergens [26], [27], [28], however, incidence increases markedly after the age of 2 3 years mainly due to sensitisation to aeroallergens [26].
No large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured.
Indeed, resistance to taxanes can be induced in cultured human tumour cells by transfection with βIII-tubulin, whereas βIII-tubulin depletion in cells resulted in the sensitisation to taxanes (Lu and Luduena, 1993; Panda et al, 1994; Kavallaris et al, 1999; Kamath et al, 2005; Shalli et al, 2005; Gan et al, 2007).
Moreover, IR resulted in a sensitisation to TRAIL-induced apoptosis in one RCC cell line only.
The MGMT inactivation by PaTrin-2 in MCF-7 cells resulted in marked sensitisation to temozolomide growth inhibition.
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