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In programmed cell death (apoptosis), levels of the proapoptotic molecule BAX become elevated [ 13].
For example, in 2004 Angela Cox's group at the University of Sheffield looked for correlations between breast cancer and the sequences of genes involved in programmed cell death.
Besides, proline metabolism was also involved in programmed cell death and plant-pathogen interaction.
Hence, further studies are required for the better understanding which molecules shows bioactiveness and which pathways are involved in programmed cell death.
Recently OsAP25 and OsAP37 have been reported to be involved in programmed cell death for development of embryo (Niu et al. [2013]).
Some of them involved in programmed cell death process regulation in plants, thereby improve the survival rate under the adverse conditions (Solomon et al. 1999).
Most of the "upregulated" genes produce compounds known to activate immune cells--so-called cytokines and chemokines--or are involved in programmed cell death.
BH3-interacting domain death agonist (BID) and clusterin (CLU) are two other potential therapeutic targets that are involved in programmed cell death.
The mazEF TAT module, first characterized in E. coli [71], [72], is found on the chromosomes of many bacteria and functions in programmed cell death [73].
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Interestingly, a delay in programmed-cell-death (PCD) associated with TW was also clearly observed and readily quantified by μCT.
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