In this study, we investigated COX-2 expression in IPs, IPs with dysplasia, IPs with squamous cell carcinoma (SCC), and primary SCCs of sinonasal tract.
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Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed.
[F]FDG-PET/CT imaging has demonstrated high FDG uptake in IP with coexistent carcinoma, however the material in this study was small and further studies are required.
The following media groups were created: DMEM, which is formed by osteoblasts in basal medium; IP DMEM, which is formed by osteoblasts in IP with basal medium; OST, which is formed by osteoblasts in osteogenic medium; and IP OST, which is formed by osteoblasts in IP with osteogenic medium.
As elevated PCNA expression showed in IP with malignant transformation from our survey, we suspected the PCNA to be important factor to induce cancerization for patients with sinonasal IP.
The concentration of Si ions was 40.91 mg/L in IP DMEM medium (which is formed by osteoblasts in IP with basal medium), 41.28 mg/L in IP OST medium (which is formed by osteoblasts in IP with osteogenic medium) and lower than 1 mg/L in the media with no contact with BG60S (DMEM and OST, which are formed by osteoblasts in basal medium and osteoblasts in osteogenic medium, respectively).
