Artists know that very well, as do politicians, journalists, advertisers and business people, who practically base their existence on the downfall of one thing in order to be able to create, relate or invest in the insurgence of a better model.
PML, RFP, TIF, and EFP are implicated in tumor insurgence and progression [ 11- 14].
KCTDs are involved in the insurgence and the progression of severe human pathologies including cancers, epilepsy and obesity [ 12– 12].
Aberrant methylation of these master regulators may play a crucial role in the insurgence and/or progression of breast cancer.
According to our analysis, our method is able to detect already well-known genes and identify new genes potentially involved in the insurgence and progression of tumor.
More specifically, our results are suggestive of a critical role of homeobox gene methylation in the insurgence and/or progression of breast cancer.
Studies showed that homeobox genes, such as the TLX1, HOXB13, and HNF1B genes methylation play a critical role in the insurgence and/or progression of breast cancer [ 42].
Some of these genes are involved in the insurgence of human disease; for instance, T04A8.7 is orthologous to human acid beta- d-glucosidase gene (GBA), which when mutated leads to Gaucher disease [15,16].
Considering that complex diseases are characterized by the alteration of many different genes, the identification of new interactions with a gene involved in the insurgence of a disease could provide a significant contribution to identifying key players involved in the same disease in addition to potentially identifying novel drug targets.
The myths of Mirabai, the legendary Hindu poetess-saint, and Antigone, the mythical figure of insurgence in Greek tragedy, are useful in understanding the notion of yearning as a rational passion linked to bodily experiences (1998, chap. 5).
Participants were free to leave the study in case of insurgence of new severe illness.
