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Using a transgenic mouse model characterized by CNS hypermyelination, we show that larger myelin content results in greater severity of experimental autoimmune encephalomyelitis attributable to an increased number of microglia within the hypermyelinated brain.
Even more importantly, the adrenergic inotropic and chronotropic actions result in greater severity of post-resuscitation myocardial dysfunction.
Consistent with previous studies [ 1, 19, 25], the frequency of L. pneumophila infection was very low (<2%) and was not implicated in greater severity.
It has been observed that mutations in TSC2 result in greater severity of renal disease, and a number of studies have analysed the genotype phenotype correlations [ 8, 9].
Among adults, Tukel et al. [ 50] found that OCD with any comorbidity resulted in greater severity of both obsessions and compulsions.
Infections with resistant organisms not only result in greater severity and higher rates of morbidity and mortality, but also increase health care treatment costs and long-range expenses related to research and development of new drugs.
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Our American Indian population differs from such cohorts in its greater severity and duration of diabetes, and in its predominance of women, rather than men.
In contrast, our study showed that chemerin treatment resulted in a greater severity of DSS-induced colitis.
Working alone is generally taken to increase a worker's vulnerability, and the proportion of lone workers injured through physical assault is estimated to be 9% higher than for non lone workers (NHS Protect 2017b) and is thought to result in a greater severity of assault (NHS Protect 2015).
More animals were operated in experimental groups of greater severity in anticipation of attrition.
In other words, if patients in hospital had greater severity of illness, greater medical visit intensity may have been required.
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CEO of Professional Science Editing for Scientists @ prosciediting.com