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As a result, even though the proportion of PSS matching human ABS was actually similar at DRB and MHC class I, as many as 6 PSS were detected outside ABS in DRB, which was also reflected by high dN/dS ratios at non-ABS DRB sites.
Table 1 Description of selected gauging sites in DRB S. no.
Open image in new window Fig. 1 Location of gauging sites in DRB.
To retain the nutrients in DRB, especially protein fractions, thermal pretreatment followed by enzymatic hydrolysis without washing step was applied for saccharification.
The objectives of the present study are to: (i) extend FDC application to extreme low flows determination, and (ii) assess EFs in six different watersheds in DRB.
The design EFs values for 7Q10 range from 2.04 to 5.56 cumec, whereas for 7Q100 range from 3.4 to 31.48 cumec in DRB.
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RNA FISH analysis of primary transcripts demonstrated that inhibition of transcription with DRB or α-amanitin was indeed very efficient, with the percentage of cells showing active globin transcription going down from >70% in untreated cells to ∼3% and 0% in DRB- and α-amanitin-treated cells, respectively (Figure 1B).
To investigate the role of p53 in DRB-induced apoptosis, specific p53 inhibitors were used.
We therefore investigated whether intrinsically generated high cytosolic p53 levels in DRB-treated cells were coupled to activation of Bax.
However, not only is the CpG level high in DRB1-e2, but also the CpG pattern is highly conserved in DRB-e2.
To further investigate the role of mitochondrial p53 in DRB-induced apoptosis we used pharmacological manipulations to distinguish nuclear and mitochondrial p53 functions.
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