In deletions of ptc1, which encodes a protein phosphatase 2C, 24% of cells exhibited septation and/or chromosome segregation defects exemplified by off-center septa and unequal distribution of the daughter nuclei.
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Although the data clearly points to a spike in deletions, this process is likely still underway.
This error-prone process often results in deletions of varying lengths at the targeted locus.
In his pronouncements, Maas referenced a new report by the Jugendschutz organization, a youth protection watchdog, which showed that social platforms were often achingly slow to act on hate speech, and ineffectual in deletions.
We found that this reduced activity was due to recombination of the expression cassette repeat sequences during the transduction of the lentiviral vector, which resulted in deletions of one or multiple cassettes.
In VgJ1 rearrangement, diversity of junction expressed in N-nucleotide gains but not in deletions was the main factor that differed between subgroups (2x more N-nucleotides in effective primers).
In the case M13, the Cry1Aa and Cry1Ac toxins were not properly displayed resulting in deletions of the Cry1Aa-fused protein, while the displayed Cry1Ac protein did not bind to functional receptors in vitro suggesting structural constraints of the toxin (Marzari et al. 1997; Kasman et al. 1998).
These mutations frequently consist in deletions in the 11q23 region that encodes the A subunit [16], [17].
Deficiencies in polymerase proofreading activity, for example, might cause an increase in mutation rates, whereas incorrect non-homologous end joining might result in deletions or other polymorphisms.
This pathway may relieve a cell of persistent genotoxic stress imposed by irreparable DSBs, though it may result in deletions of genetic materials encapsulated in MN.
