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In CSCs derived from multiple xenografts, we observed a significant reduction in CSC growth.
Does BMP signaling have different effects in CSCs and non-CSCs defined by conventional criteria?
Both in CSCs and non-CSCs, this marker distribution was detectable.
Cx43 was expressed at much lower levels in CSCs than in non-CSCs.
Whole-cell voltage clamp analysis revealed reduced potassium current density in CSCs compared with non-CSCs (data not shown).
The authors interviewed 25 managers, 49 officers, 50 prisoners in segs and 17 in CSCs.
The average stay in CSCs is more than 40 months, but the overwhelming majority – 71% – of those on the general units spend less than 14 days in segregation.
As such, a number of mechanisms of chemoresistance have been identified in CSCs.
Activation of these DNA repair proteins in CSCs can impair the efficacy of ICL agents.
The asymmetric segregation of NuMa is likely to play a role in CSCs as well.
For these reasons, SOX2 has been heavily investigated in CSCs in several cancer types.
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