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In CPA treatment, T cells are essential for the eradication of established tumors [67], and CPA treatment seemed to be more effective on large tumors than on small tumors.
In CPA, sensors are partitioned into several groups based on their measured connectivity between nodes instead of their location information.
In CPA, the connectivity level for every node is firstly measured, and complexity of calculating the connectivity level is O(n2).
In CpA (TpA after conversion) homozygotes, with no contribution from the methylated CpG allele, both fluorescent signalMeth and signalUnmeth were very low compared to those in CpG homozygotes or in heterozygotes (see Fig. 3a- lower panel).
In CpA alleles, we intuitively expected β values to be very low, indicating non-methylated status of the interrogated TpA dinucleotide (CpA allele, being no longer "methylable", is converted to TpA after bisulfite treatment).
2 Since our first publication, we have shown that CPA assessment in HCV post-LT patients correlates with both Ishak stage scores and HVPG, with greater percentage changes in CPA, compared with HVPG in early portal hypertension.
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Significant differences in CPA-2 population level dynamics were observed in results obtained by qPCR and dilution plating.
Intracellular levels of ALDH1 and nuclear c-Myc, for example, were more prevalent in CPA-treated tumors (Figure 4C).
Interestingly, ALDH1 staining in CPA-treated tumors appeared to localize to the apical surface, where it may be hypothesized to intercept CPA metabolites as they enter the cell.
Based on Poisson distribution statistics, TG cells were >2.2-fold more frequent in CPA-treated tumors than in mice administered vehicle (P = 0.0016; Table 1 & Figure 2A).
The trend towards more frequent ESA+CD44+ cells in CPA-treated tumors generally held true independent of tumor volume and was more pronounced at higher CPA doses (e.g. 38 mg/kg versus 25 mg/kg; data not shown).
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