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Generally, if someone knows the high pathogenicity of TB bacteria, he will be on guard consciously in contacting with TB patients.
A number of hydrophobic residues, including Phe107, Phe172, Leu111, Leu114 and Leu142 from helix h4 h8, are involved in contacting with the phenyl ring, while residues Asp94, Asp149, Arg145 and Arg148 interact with O1 and O2 atoms of resorcinol via a hydrogen bond network mediated by two water molecules, W1 and W2 (Fig. 3b, 3c).
These potential hydrogen-bonding acceptors play a critical role in contacting with the high density of hydrogen-bonding donors in P-gp transmembrane sequences: TM4, TM5, TM6, TM11 and TM12 [ 33].
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