Exact(24)
The observed increase in CD8+28+ T lymphocytes in the first 2 groups which are dominated by younger people who declared higher alcohol consumption could be in confirm of the impact of alcohol on the studied immune parameter.
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In CONFIRM, reduction in risk of 3-month CDP was not significant compared with placebo, regardless of whether DMF was administered twice or three times a day [ 34].
In CONFIRM and DEFINE, mean lymphocyte counts decreased by approximately 30%% during the first year of treatment with DMF and then remained stable [ 137, 147, 148].
In CONFIRM, patients were randomized to receive DMF 240 mg BID or TID, placebo, or glatiramer acetate (GA; reference comparator) 20 mg injected subcutaneously once daily for up to 96 weeks.
In CONFIRM, patients were randomized 1 1 1 1 to receive treatment with placebo, DMF 240 mg BID or TID, or GA (reference comparator) for up to 96 weeks.
Similar(35)
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