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In comparator series 2, 6 out of 7 complex mutations were in ER-negative cases, of which four were TNBC.
In comparator series 1, 25 out of 87 ER-positive and 4 out of 4 ER-negative cases contained TP53 mutations.
Sneed et al. [ 23] also found higher response rates in patients in comparator trials (60% response) compared with placebo-controlled trials (46% response).
It should be noted that the slopes of the relationships between CV events and percentage of included diabetics were less marked when it came to comparing PO vs. CHD events rates, both in comparator and treatment arms, on one hand, or when it came to comparing PO or CHD events rates in treated arms vs. comparator arms, on the other hand.
Impact – Clients of both project noted positive interactions with health workers using the eMNH and eNutrition tools compared with the experience of clients in comparator sites.
Third, the estimated RR of achieving NEDA status for fingolimod versus placebo in the pooled FREEDOMS population (from the 'estimated' models) and the predicted RRs for fingolimod versus placebo in comparator trial populations (from the 'predicted' models) were compared with those calculated for DMF and teriflunomide in their respective trials.
Similar(14)
Additional examples of studies which could be conducted in crises should include outcome assessments as well as quasi-experimental designs where there is a built-in comparator and cross-culturally validated assessment tool.
Competition would still exist as the winning tender would be compared with an in-house comparator in March 2014.
No extrapyramidal reactions were reported in the granisetron group compared with 13 in comparator-treated patients (8%).
Terminating person-time in comparators at the matched PC patient's death or loss to follow-up resulted in comparable person-time up to 30 months of follow-up and lower person-time among comparators thereafter.
Overall, using multivariate analysis, the risk of gametocyte carriage by Day 14 was lower in comparators than in DP groups (P = 0.002, stratified by site)(figure 3, table S2).
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