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These findings seem to indicate that MyD88 is a key regulator in collective mode.
We therefore used N = 1000 to determine the linear regressions of expression changes distributions in collective mode.
Also in collective mode, for all genotypes, we notice scalable response and emergent linear behavior arise when ORFs are grouped.
Furthermore, in collective mode, the transition from large scatter in expression distributions for single ORFs to smooth linear lines emerges as an organizing principle when grouping of 50 ORFs and above.
Investigating further the temporal response of acute-stochastic and collective modes we observed auto- and cross-correlation profiles of acute-stochastic mode is similar to immune-related genes whereas the average response of randomly selected 80 ORFs in collective mode is scaled to genome-wide response (Figure 4G H, and Figure 3A), thus demonstrating that collective mode is scalable.
In general, the emergent smooth lines in collective mode can be presented by y = αx+β (Figure 8A C) where slope α represents net outcome between transcriptional and mRNA decay machineries on average expression change and y-axis interception, β, implies contribution from the equilibrium state of transcriptional and mRNA decay machineries.
Similar(54)
The long-range radiative coupling between QDs in an ensemble can be interpreted in terms of successive emission and reabsorption of photons resulting in collective modes of several QDs.
We observed i) large scatter in expression distributions around the origin for ORFs in the collective mode and ii) linear expression distribution of ORFs in the acute-stochastic mode (Figure 6A F, left panels).
(Chinen) Angelica Sanchez Trio (Saturday) Ms. Sanchez, a probing pianist, has worked often in a collective mode with the members of this trio: Tony Malaby, a smartly blustery tenor and soprano saxophonist, and Tom Rainey, a starkly suggestive drummer.
Next, we compared groups of upregulated ORFs in the collective mode of wildtype (WTc+) (x-axis) with MyD88 KO and DKO (y-axes) (Figure 6A and C, right panels).
From these values, MyD88-dependant (M) and TRIF-dependant (T) pathways are important for transcription while MyD88 & TRIF-dependent synergized processes (MT) are insignificant (in contrast to collective mode, see below).
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