Sentence examples for In ccv from inspiring English sources
Eps15 is usually co-localized with AP-2 at the plasma membrane or AP-1 at the TGN [58] but is excluded from CCVs, but its role in CCV formation has not yet been defined [59], [60].
Switching between vowels in CCV sequences complicated the reading task.
These CCV components can, as is demonstrated by Hrb's role as an ArfGAP, have other roles in CCV formation.
The 30 kDa bilobal C-terminal appendages of α and β2 each possess two sites for binding different motifs found on many other endocytic CCV coat proteins with various accessory/regulatory functions in CCV formation (reviewed in Owen et al., 2004; Schmid and McMahon, 2007).
We further show that this is not only a common event employed by other GPCRs like the β2-adrenergic, vasopressin V2, bradykinin type 2, platelet-activating factor and endothelin A receptors but that the epidermal growth factor receptor is capable of eliciting the phosphorylation of AP-2 in CCVs.
Clathrin itself and clathrin-mediated vesicle formation are highly conserved in evolution and one could speculate that the major protein homologues involved in CCV-formation have similar importance in different species.
By contrast, a similar depletion of Dab2 led to markedly decreased CFTR endocytosis and CFTR content in CCVs (20).
In both graphs, receptors in CCVs are responsible for the width of the distribution at 3 min (red curves in C and D ).
Consistent with this interpretation, a more limited (~60%) knockdown of µ2 adaptin caused no difference in either CFTR endocytosis or CFTR content in CCVs.
The same study showed that HIP1 is present in CCVs purified from human brain extracts, and that HIP1 co-localizes with endocytosed cargo in cultured COS-1 cells, although only a subset of CCVs were positive for HIP1.
2) The authors favor a model in which trapping of endocytic proteins in CCVs that fail to uncoat in absence of OCRL-mediated PI 4,5 P2 hydrolysis indirectly causes stalling of CCP dynamics and an accumulation of u-shaped CCPs.
