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Cells deficient in CCO, but marked by porin, indicate cell patches with CCO mitochondrial DNA mutation (Nicholson et al., 2011).
Here, we summarize the current knowledge on the identity of the structural elements involved in proton transfer in CcO.
These variants are designed to provide unique labeling sites for probes to be used in spectroscopic experiments investigating the mechanism of proton pumping in CcO.
Deflecting offenders in 25 T, combined with offender presence in CCO, plus security 'decoy' attractions (described above) led to Deflect from/Direct to.
In addition, excessive NO produced in response to Aβ1-42 accumuledion led to a decrease in CCO activity and ATP levels.
The enhancement in NO production in the lens epithelium based on positive feedback (NO-Aβ positive feedback loop, a vicious cycle) may promote the onset of cataracts (lens opacification) via the decrease in CCO activity and ATP levels.
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Thus, the well-known proportionality between the oscillation frequency and the bias tuning current in CCOs is avoided for the entire achieved tuning range, resulting in a lower power design.
On examination of the lower conducting airways, the frequency of Clara cells in CCO-active lung epithelial cells matched with that of the neighbouring tissue.
Significantly, on examining the cell types within CCO-deficient patches, only ciliated and basal cells were always present in CCO-deficient patches with more than five cells, consistent with murine data identifying basal cells as the most likely host of multipotent progenitors of the upper airway.
They also all contain the two essential genes for the archaeal heme-copper oxidase/CCO complex (subunit I and II) [ 70], and we confirm that subunit II contains the Cu-binding motif generally found in CCOs [ 71] (Additional file 19).
In contrast, if CCO decrease is abnormal over a stenosis, further non-invasive testing should be considered.
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