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The modeling approach is similar to what has been previously described (Berhane and Molitor 2008; Jerrett et al. 2010), but it includes a richer random-effects structure on all growth curve parameters for better control of subject-to-subject heterogeneity than we have previously used in analysis of this data set (Jerrett et al. 2010).
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The authors acknowledge that the variability in quality observed in the analysis of this data highlights the difficulties of conducting epidemiological research across countries and continents; it is a limitation of this analysis.
But where "data computing" comes into its own is in the analysis of this data to identify trends and extract actionable information -- in other words, to find the answers.
Therefore, computational tools to assist in the analysis of this data are essential.
Merck and Co. Inc. performed the analysis of the serum and tissue drug concentrations but did not participate in the analysis of this data.
A chrII 516,338) QTL, containing the AMN1 gene [also identified in the analysis of this data by Gagneur et al. (2013)] was mapped for doubling time in glucose.
In our analysis of this data we detected 21 genes with mislabelled sequences (incorrect taxon names, confirmed by the authors) which we removed from the dataset.
The authors wish to thank Dr. Rosana Pellizzari and the Peterborough City-County Health Unit for involving us in the analysis of this data, as well as Michael Ladouceur at the Ontario Ministry of the Environment for the data collection.
An important problem that arises in the analysis of this data is determining if a set of genes are collectively regulated by a set of transcription factors and whether this combinatorial regulation changes when the cell is exposed to stress.
Further analysis using an in-depth qualitative analysis of this data is necessary to answer this question.
We included 12 countries in this systematic analysis, one third more countries than were included in the previous analysis of this data in The Lancet Every Newborn series [ 4].
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