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The second NEAT domain of IsdB is structurally similar to other heme binding NEAT domains, and heme-iron is coordinated by a tyrosine residue as predicted; however, we have also shown that Met362 coordinates the heme-iron on the distal side, resulting in an unprecedented mode of heme-iron coordination.
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However, an unprecedented mode of gene loss was discovered in the lineage spanning R. canadensis and TG rickettsiae, illustrating that gene signatures alone may not well-characterize specific rickettsial groups, but instead the modes of gene loss (and stricter reliance on host resources) may be the defining features [175].
It follows that if the environment is changing in an unprecedented way, then the changes too will be unprecedented.
Crypto and blockchain has weaponized nerds in an unprecedented way.
Recent technological innovations have advanced genomics in an unprecedented way.
But in an unprecedented move Ms. Sebelius overruled the agency.
This new structure has revealed a previously unprecedented mode of β-propeller dimerisation involving blade hybridisation.
The Blogosphere is expanding in an unprecedented speed.
France and Italy are locked in an unprecedented feud.
New car sales in Europe are in an unprecedented swoon.
Women recently voted in an unprecedented election in Iraq.
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CEO of Professional Science Editing for Scientists @ prosciediting.com