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This fact is an argument in favour both of their long-term investment and in alternative study designs using markers of disease initiation as earlier outcome measurement.
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In this structure, the backbone amide of the small subunit Cys is approximately 3.0 Å from Fe and at this resolution it is impossible to claim this provides a ligand for the metal ion, as has been suggested in alternative studies [ 14].
In an alternative study, phage-mediated transduction of E. coli with an inactivated LexA protease was shown to greatly hypersensitize the bacteria to traditional antibiotics.
In fact, an alternative study to the one developed in this paper can be done to model this type of trajectory.
We monitored shade avoidance by observing changes in students' use of the unshaded alternative study site in intervention compared with control schools.
So I go on writing in the hope that, 150 years from today, what I turn out may be used as an alternative study in, say, Durham University.
Thus, the most attractive alternative study design in such instances becomes the before/after study.
The approach permits researchers to compare alternative study designs, in terms of their statistical power.
Vaso-pressin was probably the most effective alternative studied in both experimental and clinical trails.
High response rates, however, are particularly difficult to achieve in studies on migrants, and alternative studies, like qualitative studies and focus group discussions would add useful information here.
In alternative models, we studied the consequences of assuming diagnostic errors.
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