Your English writing platform
Discover LudwigExact(1)
In addition, GHRKO mice are markedly insulin-sensitive, tend to be hypoglycemic, have reduced body weight and size, reduced incidence of neoplastic disease and a pronounced increase in all lifespan parameters, including increased mortality rate doubling time (MRDT), as well as median, average and maximal lifespan [10], [13], [14].
Similar(59)
After all, lifespan in a protected environment may predominantly reflect the force of mortality due to intrinsic causes (higher maintenance requirement for bigger individuals) whereas mortality in the wild may predominantly reflect death form extrinsic causes (lower mortality from extrinsic causes for bigger individuals).
In all chronological lifespan measurements, aliquots removed from cultures at the indicated times were plated in triplicate on YPD agar to determine survival (as colony forming units).
At least 25 worms were used in each lifespan assay and all lifespan assays were repeated at least twice.
The log-rank p values are reported for all lifespan data in this study.
In all cases, the lifespan of mutant females was significantly lower than the lifespan of control females (Table 1, Figures 3D-G).
Although a single term [dietary restriction (DR)] is often used to refer to this intervention, there exist a number of methods of restricting nutrients that all result in lifespan extension in species ranging from yeast to mice (Goodrick et al., 1990; Mair et al., 2005; Masoro, 2005; Dilova et al., 2007; Mair & Dillin, 2008; Piper & Bartke, 2008; Skorupa et al., 2008).
Age-specific mortality plots are in agreement with left-censored survival results, with low aging-related mortality in all backgrounds where lifespan extension is significant (Fig. S4A and S6A C).
In all cases, the lifespans were significantly shorter than that of Dahomey and exhibited median lifespans from 53 days for OregonR to 65 days for Dahomey.
All studies used female mated flies as they show the biggest difference in lifespan in response to changes in yeast in the diet.
Mutations in TOR usually result in a 30% increase in lifespan; IIS mutations usually result in a doubling of lifespan.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com