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Differences in A-states and R-states predominately involve the configuration of a long cleft that divides the myosin MD into upper and lower 50 kDa subdomains, the so-called actin binding cleft.
In a state of constant stress.
People live in a state of uncertainty.
Scotland are in a state of unrest.
We are in a state of suspension.
We were in a state of flux".
Are you in a state of shock?
"I'm in a state of terror".
Diyarbakir was in a state of upheaval.
I'm in a state hospital.
I was in a state of shock".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com