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Accuracies of DGV for five production traits using imputed 50K genotypes were close to those obtained with the actual 50K genotypes and higher compared to using 3K or 7K genotypes.
Imputed results are presented.
The results may be used to compare the cost efficiency of commercially available arrays, to assess the power to detect trait associations using imputed allelic dosages, and to design custom arrays.
The accuracy of genomic prediction decreased by 15.9 to 21.9 % across the three traits when it was based on imputed genotypes with very low accuracy (on average equal to 0.68 and 0.57, respectively).
We aimed to test association between the trait smoking and the genotyped or imputed genotypes in this region.
Missing trait data (0 4.5% of data) were imputed by default parameter settings which uses an average of three nearest neighbor values.
These gains ranged from modest (2 5%) to substantial (10 24%), depending on the trait (regardless of whether GBS genotypes were imputed) and on the statistical method used to incorporate GBS data (either GBLUP or RKHS).
Additionally, Genomic Best Linear Unbiased Predictor (GBLUP) [ 17] was used to estimate the narrow-sense heritabilities of the traits for single and multi-site using genotypes from imputed data produced by the EM algorithm with 30% missing data.
Finally, trait-specific and rare variants may be poorly imputed from the typed markers.
However, when genotypes were imputed with high accuracy, results for genomic evaluation were promising for several traits in a commercial pig population (Cleveland and Hickey 2013).
The average gains in prediction accuracy varied greatly across traits and imputation methods, and in some cases methods that use imputed genotypes or inferred haplotypes were outperformed by methods based on called genotypes only.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com