Sentence examples for Impaired delivery from inspiring English sources
Unfortunately, metronomic S-1 dosing resulted in impaired delivery of PEG-coated "cationic" liposomes into tumor tissue, presumably by decreasing the binding sites on tumor blood vessels available for the liposomes.
In this scenario, one of the consequences of septin deletion in U. maydis would be a less solid cell wall unable to support physical pressure as a consequence of an impaired delivery of cell wall material.
We found no impact on general autophagy rate in patient fibroblasts, and importantly, there was no impaired delivery of mitochondria to lysosomes.
After autophagy inhibition, P62 accumulates and leads to the impaired delivery of UPS (Ub-proteasome system) substrates to the proteasome (Korolchuk et al., 2009a).
This hydrolysis could be attributed to an impaired delivery of retinol to esterifying enzymes, above all LRAT, that requires CRBP-1-bound retinol as a substrate [ 108].
Yet it is the unbound oxygen that is utilized in cellular respiration; and in disease, the balance between the bound and unbound oxygen can be compromised due to impaired delivery and/or consumption.
Severe acidosis in sepsis is associated with haemodynamic instability through many different pathophysiologic mechanisms (reduced left ventricular contractility, diastolic dysfunction and right ventricular failure, predisposition to cardiac arrhythmias, arterial vasodilation, impaired responsiveness to catecholamines, reduced hepatic blood flow, impaired oxygen tissue delivery) [27].
Delayed gastric emptying (GE) occurs frequently in critically ill patients and may result in impaired small intestinal delivery of drugs and nutrients.
Impaired blood and oxygen delivery to the vascular beds of active muscles can result in repeated muscle exposure to functional ischemia [12].
Abnormal maternal thyroid function is associated with various maternal and fetal complications such as preeclampsia, miscarriage, preterm delivery, and impaired neurodevelopment of the child [ 2– 8].
