In order to assess its central nervous system penetration, we measured raltegravir concentrations in cerebrospinal fluid (CSF) and plasma in subjects receiving antiretroviral treatment regimens containing this drug.
However, it appears to exhibit less central nervous system penetration, which could suggest a lower seizure-inducing potential.
Since central nervous system penetration of this compound may occur, it has been believed that it might be used to the development of therapeutic agents against glioblastoma [ 132].
35 Even though it is possible to analyse the Central Nervous System Penetration Effectiveness (CPE) scores 36 of the HAART regime of the study subjects, the cross-sectional methodology limits meaningful interpretation of the results as many other confounders such as duration of treatment and the timing of treatment initiation need to be considered.
Doxycycline, another first-line agent, should not be used if meningitis is suspected because of its lack of adequate central nervous system penetration.
However, clindamycin is not appropriate for the treatment of endocarditis because of a high rate of relapse, presumed to be due to its bacteriostatic action, nor is it appropriate for meningitis because of poor central nervous system penetration.
- It is an inexpensive orally available drug that has central nervous system penetration.
One of the obstacles to increased DC system penetration is the lack of standards.
Results from both experiments demonstrate that Themis reduces traffic congestion and average travel time at various traffic densities and system penetration rates.
Preterm infants are at increased risk for hematogenous Candida meningoencephalitis owing to increased permeability of the blood-brain barrier, so antifungal treatment should have adequate central nervous system penetration.
In addition, meropenem was discontinued after 6 weeks and switched to ceftriaxone 2 grams IV every 12 h for more reliable central nervous system penetration.
