The SCID-I will be administered by telephone, by psychologists who received a specific training for this.
During phase I studies, capecitabine will be administered according to the dose-finding scheme reported above, therefore at a daily dose ranging from 500 mg/m2/bid to 825 mg/m2/bid, for 21 days starting on the day before the beginning of radiotherapy.
Radioimmunotherapy will be applied according to SmPC, i.e. cetuximab will be administered as loading dose and then weekly during the radiotherapy.
Subsequently, the Mini-International Neuropsychiatric Interview (MINI [ 49, 50] will be administered for the classification of symptoms and the diagnosis of major depressive disorder.
The Wechsler Preschool Primary Intelligence Scale – Australian Standardized Version-III (WPPSI-III Australian; [ 139]) -- will be administered to assess the children's intellectual functioning in general, verbal, performance, and cognitive domains.
If there are no contraindications, 20 to 40 mg butylscopolaminiumbromide will be administered i.v. to reduce bowel movement and therefore the physiological glucose uptake.
Prior to reperfusion 500 mg Prednisolone will be administered i.v. After the transplantation, a combination of anti-CD25-mAB (basiliximab 20 mg on day 0 and day 4 after the procedure), and MMF 2 g/d, 2 applications per day i.v., later conversion to oral intake) will be applied.
The treatment drug will be administered "blind" i.e. the doses are not identifiable since the packaging has the same format, presentation, and visual characteristics.
For the dGEMRIC series, immediately after the clinical and T2 imaging a double dose of Gd-DTPA (Magnevist, Schering, Berlin) will be administered intravenously i.e., 0.4 ml/kg (0.2 mM/kg).
Self-administered questionnaire on completion of programme will be administered.
It will be administered by government officials.
