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We designed a phase I trial to investigate the safety, immune responses and clinical benefits of a five-peptide cancer vaccine in combination with chemotherapy.
This year the company launched a phase I trial to evaluate the safety of CVM-1118 in people with a variety of untreatable cancers and to assess its effectiveness.
We undertook this phase I trial to assess the safety, the recommended dose for phase II trials (RPTD), pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary antitumour activity of the combination of lapatinib and sorafenib in patients with advanced refractory solid tumours.
We describe the design of a seamless, multi-site randomized Phase II/III trial to evaluate an asthma management intervention in urban adolescents with asthma.
The Radiation Therapy Oncology Group (RTOG) protocol 95-17 was a Phase I/II trial to evaluate multicatheter brachytherapy as the sole method of adjuvant breast radiotherapy for Stage I/II breast carcinoma after breast-conserving surgery.
We are also conducting a phase Ib/II trial to evaluate the maximal tolerated dose of CRLX101, a nanoparticle formulation with camptothecin-cyclodextrin-PEG polymeric prodrug, when combined with neoadjuvant therapies capecitabine and radiotherapy (NCT02010567).
Similar(20)
Defence R&D Canada has been conducting SAR-GMTI trials to assess the performance and limitations of the RADARSAT-2 GMTI system.
An overall sample size of 40 is generally considered appropriate in first Phase I trials to estimate the incidence rate of frequent AEs with an acceptable accuracy, allowing for dropouts.
27 Moreover, phase I trials to evaluate it in combination with other drugs are ongoing.
40 Belinostat was first investigated in several Phase I trials to determine the maximum tolerated dose (MTD).
Diverse compounds have been developed and are in phase I trials to define the maximum tolerated dose; the next step will be phase II trials.
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