Sentence examples for I trafficking from inspiring English sources

Recent data from our laboratory demonstrated that MHC I trafficking is controlled by a highly conserved tyrosine located in the cytoplasmic tail of the class I molecule.

In addition to MHC I trafficking, HCMV has evolved mechanism(s) that alter MHC II expression.

The next step in MHC I trafficking along the secretory pathway chosen by herpesviruses is their rerouting in the trans-Golgi towards rearranged late endosomal compartments.

The primary target for CMVs will be modulation of antigen presentation in the endosomal system, either by retrieval of MHC I loaded with viral peptides into endosomal compartments or redirection of MHC I trafficking and disruption of endosomal peptide loading.

The activity of U24 does not affect MHC I trafficking but inhibits constitutive recycling of the T-cell receptor complex (TCR-CD3) in infected CD4 T lymphocytes and retains them in Rab4+ and Rab5+ early endosomes.

Immunoprecipitation experiments suggest an interaction between CopA in the E1·Cu(I) state (vide infra) and apo-CusF that is fully consistent with a model of Cu(I) trafficking to CusF during a productive CopA ATPase cycle.

HhRz VAI traffics predominantly to the cytoplasm to colocalize with the RHO mRNA target.

This suggests that a small portion of MARCH-VIII traffics to the cell surface.

Collectively, our results support the model of DC MHC-I trafficking and exogenously-derived peptide loading depicted in Figure 7.

While the results presented here provide an important first step for delineating intracellular routes of MHC-I trafficking in DCs and defining the molecular mechanisms that contribute to cross-presentation, many questions remain unresolved.

PC-III behaved as expected from our previous experiments on PC-I trafficking (Bonfanti et al., 1998; Mironov et al., 2001; Trucco et al., 2004).