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Importantly, these data present a mechanistic basis for the requirement of A12.2 in Pol I termination.
We conclude that not only RNA stability, but also Pol I termination itself is affected by the loss of Grc3.
However, quantitative analysis of K252A produced a Pol I termination profile similar to that obtained after Grc3 depletion.
Next, we aimed to determine whether the effect of Grc3 on Pol I termination is mediated by its polynucleotide kinase activity.
An interim analysis was performed after phase I (termination criterion: unacceptable toxicity) of the study and after treating 10 patients in phase II (termination criterion: tumor progression within 10 weeks in more than 8 patients).
Depletion of Rai1 or Grc3 impairs Rat1-dependent degradation of the 3′ trailing transcript in RNA polymerase I termination (El Hage et al, 2008; Kawauchi et al, 2008; Braglia et al, 2010).
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Is termination of pregnancy associated with a higher risk of placental implantation or retention problems (ie, placenta praevia, placental abruption and retained placenta) in a subsequent pregnancy?
"I chose termination because I believe that child was telling the truth".
As I understand it, termination of the contract simply caps the pension at the point of termination.
Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop.
Is medical termination of pregnancy safe in the presence of a uterine anomaly?
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