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In a 7-day repeated dose study with 0.5 mg/kg dose, a sustained, significant effect was seen.
A good sustained effect and a moderate bioadhesion were obtained with the tablets.
The findings suggest that Cathinone might have a sustained effect as peripheral vasoconstrictor among regular Khat chewers.
We therefore speculate that apelin agonists, such as MM07, that may have a sustained effect at the apelin receptor would be beneficial in these conditions.
In the first weeks of using modafinil, I felt a bout of happiness, a steadily upward-moving mood; a strange and sustained euphoric effect.
Now the term "sustained effect" describes the formerly "persistent effect" which may lead to some confusion.
Similar to our study, there was no evidence for a sustained effect thereafter [20].
Different strategies are employed to obtain a sustained effect from these analgesics, for example sustained release oral dosage forms [2], [3], sustained release transdermal patches [4] and implanted infusion pumps [5].
Unfortunately, none of these studies has demonstrated a sustained effect over years [ 26].
Duloxetine showed higher improvement rates than placebo and had a sustained effect beyond 12 weeks.
21 Evidence has shown a sustained effect for up to 6 years after finalization of treatment with SCIT, 7, 11, 22 while for grass AIT so far there is evidence for a sustained effect 2 years after completion of treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com