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This report is part of a phase I study using escalating doses of codrituzumab in conjunction with sorafenib in patients with advanced HCC (Clinical trials.gov identifier NCT00976170).
The observed ELISA titres were comparable with those from a previous Phase I study using this vaccine [14]; (Okitsu et al. submitted).
In our previous phase I study using hydralazine at doses between 50 and 150 mg/day without accounting for acetylator phenotype, we observed demethylating and reactivating effects [46]; hence, the levels observed herein readily explain the molecular changes observed regarding methylation and gene expression.
In a phase I study using a 24-h intravenous (i.v).v
We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D).
In the phase I study using the same regimen (N=18), five patients experienced a mild neurocognitive disturbance but no RPLS was diagnosed (Diaz-Padilla et al, 2012).
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This single centre phase I study used a modified Fibonacci design with a planned minimum of three patients at each dose level.
Another powerful and common teaching tactic deployed by executives I studied, used in conjunction with the other techniques I've mentioned, was the simplest: leading by example.
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Before advising clients or making authorized trading decisions, the portfolio managers at a bank I studied use an on-line system to analyze individual portfolios.
In initial phase I studies using a continuous infusion dosing schedule in a variety of malignancies, no clinical activity was observed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com