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The MBD is unusual among site-specific DNA binding proteins in that (i) specificity is not conferred by the enhanced affinity for the specific site but rather by suppression of its affinity for generic DNA, (ii) its specific binding to mCpG is highly electrostatic, and (iii) it takes up as well as displaces monovalent cations upon DNA binding.
It is possible that anti- Mtb CARs could also be developed if a distinct target antigen could be identified that would qualify for (i) specificity of Mtb, (ii) frequently expressed by infected cells, and (iii) low or absent mutations in the target sequence.
I would tell a friend to help me relieve my mind…" When asked, "Please rank from most important to least important to you the features of a text message about test results", participants ranked i) specificity of message, ii) language, iii) privacy, iv) clarity, and v) length.
We found no SYBR Green I specificity for the sequences used, but cannot exclude SYBR Green I specificity towards specific sequence motifs.
The data of Table 1 show that the investigated compounds demonstrated lower inhibition constants for CA II and higher CA II vs. CA I specificity of compounds (3) and (4) versus compounds (5) and (6).
These results confirm recent findings that HLA class I supertypes often provide an oversimplification of the HLA class I specificity space [24], [40], [41].
Similar(47)
Yet he concedes, "Is specificity in itself satisfying?
In order to avoid possible harmful side-effects due to undesired neutralization of GnRH isoforms, GnRH-I specificity of antibodies raised against a panel of alternative GnRH antigens was determined.
In CAS complicating aggressive lymphoma, the CA are monoclonal, most often IgM, and have anti-I specificity.
Is specificity achieved through association with distinct insulator partners at different CTCF sites?
Is specificity an equally important life history trait in the context of inoculative or mass release of a biocontrol agent to maximize effectiveness?
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