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Our approach and hypotheses incorporate three crucial strategies: (i) sensitive, quantitative analysis of gene expression, (ii) principal components analysis of cognitive test scores to better reflect WS cognition, and (iii) correlation of cognitive performance with WS gene expression within a cohort of WS cases with typical deletions.
Upon treatment (i) sensitive cells are eliminated and the intrinsic resistant tumour cells survive and proliferate.
Further work is required to determine whether NCX is the only such process or whether, as has been suggested for the SAN, other mechanisms such as [Ca2+] i sensitive cation channels [48] may also be involved.
"Was I sensitive this time because the soldier wasn't a nameless African?
The highest percentage of loci with positive signals are detected with probes homologous to the DNase I sensitive sub-domains containing the locus control region (LCR) and active adult β-globin genes (HBD, haemoglobin delta; HBB, hemoglobin beta).
The pinpointing of the poly-A tail as a conformation-disrupting site by its excision was further confirmed by the finding that the poly-A tail was highly sensitive to DNase I sensitive digestion (Figure 6B).
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The other six sgRNAs designed to target Hox3 or Hox12 were not able to yield a Cel-I sensitive band (Fig. 1C), suggesting that appearance of Cel-I sensitive bands are dependent on the sequence of sgRNAs.
We detected Cel-I sensitive bands when 1.5 pg of Hox3-sg3 and 15 pg of Cas9 mRNA were simultaneously microinjected.
RIG-I and MDA5 respond differently to infection with various viral strains, with RIG-I sensitive to paramyxoviruses, orthomyxoviruses, and the rhabdovirus vesicular stomatitis virus whilst MDA5 reacts to picornaviruses [ 11, 14].
We found that both Ci-Hox3 and Ci-Hox5 were mutated by, respectively, introducing Hox3-sg3 and Hox5-sg1 expression vector with Cas9 vector (Fig. 4C,D), although we were unable to obtain a Cel-I sensitive band for Hox3-sg3.
Is it sensitive to how the control limits are calculated?
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