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Two main strategies are employed for pharmacological modulation of miRNA activity in vivo: (i) restoring the function of a miRNA using either synthetic miRNA mimics or viral expression constructs, and (ii) inhibition of miRNA function by chemically modified antimiR oligonucleotides.
Currently, two approaches are employed to modulate miRNA activity: (i) restoring the function of a miRNA using either synthetic double-stranded miRNAs or viral vector-based overexpression and (ii) inhibiting the function of a miRNA using chemically modified antimiR oligonucleotides (Fig 1).
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Specifically, we assess the ability of restoration projects to: (i) restore species diversity and vegetation structure; (ii) increase connectivity between forest fragments, and; (iii) restore assemblage composition.
For each of the reverse reactions identified in Step i, restore the constraint on its flux to [0, ∞).
Complementation analyses in PMR1-deficient cells demonstrated that expression of Pmr1p could (i) restore αSyn cytotoxicity and (ii) supress manganese toxicity.
Do we owe it to them?' Is restoring a species that humans eliminated from the earth part of our mandate to 'keep' the earth as it was?
Six of the work's seven sections are ironically titled with such slogans of the Empire as "Society Is Saved," "The Family Is Restored," and "Stability Is Assured".
"Order Is Restored To The House Of Murdoch".
Twelve weeks of food restriction or ACE-I restored the preconditioning potential in DKO and improved it in ob/ob.
Furthermore, ACE-I restored the proportional effect of preconditioning on infarct limitation and contractility improvement to the WT-level.
I restored it.
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