Exact(1)
Box I, responsiveness item 7 states, was a proportion of the patients changed (i.e. improvement or deterioration)?
Similar(59)
Interestingly, the articular cartilage under the current culture conditions did not lose its IGF-I responsiveness.
Interestingly, under the current culture conditions, the cartilage did not lose the IGF-I responsiveness during prolonged culture periods.
GH/IGF-I responsiveness varies not only between individuals but also between tissues within an individual, e.g. more GH is needed to produce an effect on IGF-I production than for longitudinal bone growth [ 34].
Platelets from insulin-resistant patients show signs of hyperactivity including (i) reduced responsiveness to the factors released by the endothelium, (ii) increased responsiveness to platelet agonists, (iii) increased levels of the α-granule marker P-selectin (CD62P), and (iv) increased expression of integrin αIIbβ3.
In particular, we evaluated (i) the responsiveness of the intrinsic NTS neurons by intratracheal application of capsaicin; (ii) the levels of the two major endocannabinoids, anandamide, and 2-AG and of the cannabinoid receptor-inactive PEA; (iii) the morphological changes in NTS microglia and astroglia.
Several mechanisms contribute to peripheral tolerance: (i) hypo-responsiveness to antigens expressed at low levels 148, (ii) deletion of activated T cells through antigen-induced cell death 149, (iii) T cell intrinsic functional inactivation (anergy) 150, and (iv) active suppression by the action of regulatory T cells (Tregs) 151, 152.
Is their responsiveness an issue for you?
Knockdown of IRF-1 and IRF-7 reduced STAT1 phosphorylation, an essential component for type I IFNs responsiveness (Fig. 4E).
I = responsiveness.
CD1 mice were chosen for this study due to the extensive earlier mechanistic studies of sex-specific liver gene expression carried out in this strain; these include global analysis of DNase I hypersensitivity, responsiveness to hypophysectomy and growth hormone treatment, and the identification of binding sites for the growth hormone-regulated transcription factors STAT5 and BCL6 [ 26- 28].
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