At this point, I recapitulate that IR increases circulating glucose and free fatty acids that are not taken up in adipose tissue, liver, and muscle, and are now freely available to all non-insulin-dependent tissues.
Cancer stem cells (CSCs) are defined by their ability to (i) fully recapitulate the tumor of origin when transplanted into immunodeficient mouse hosts, and (ii) self-renew, demonstrated by their ability to be serially transplanted.
The ideal mouse model for drug development would (i) faithfully recapitulate the genetics and molecular characteristics of the human tumor in question; (ii) posses a short tumor latency and high penetrance; (iii) be relatively simple to generate and easy to use; and (iv) ideally, would contain a built-in mechanism to assess therapeutic effects, such as a bioluminescent reporter (see below).
"I can recapitulate that game in sequence," Majerus said of the championship meeting.
In discussing my career, I have recapitulated the major phases of cancer progression to illustrate how challenges have created opportunities for me.
In order to partially validate the statin implementation and test its ability to capture known effects of the drug on the modeled behaviors, we verified that simulations in the phase I population recapitulated the increase in PCSK9 reported clinically for statin treatment.
With a more than 2-fold increase in GUS activity after a 10 h treatment at 8°C the expression pattern of the original tagged line 17 under LT stress at cell colony stage I was recapitulated in the back-transformed lines carrying the full-length 17-1 promoter sequence.
"Instead, I just see it recapitulating stereotypes about women, cruel and unattainable standards and, above all, unquestioned heteronormativity".
As mentioned, while they may lack clear functional classifications, computationally generated mechanisms, such as the Cancer Modules, recapitulate (i) known cancer genes, (ii) those predicted with curated GO pathways, and (iii) additionally provide coverage of genes that have yet to have a function assigned and would not have been discovered with the curated pathway paradigm.
MCU expression recapitulates I MiCa.
