The identification of L-type calcium channels as regulators of filopodia formation in cancer cells was unexpected as their expression and activity is principally thought to be restricted to excitable cells17,18.
In several parts of the world, notably the Southern Ocean, scientists have already noted that the waters appear to be absorbing less CO2 - although this is principally thought to be because of changes to wind patterns - and leaving more CO2 in the air should logically lead to greater warming.
Yet today we live in a culture that principally thinks only of itself and only of today.
This might not be surprising because p97/VCP binding is principally thought to be required for providing the driving force for dislocation of substrates form the ER and might not be essential for gp78-mediated degradation of cytosolic substrates like mutant htt proteins.
Interview with patient, relapsing-remitting MS (Intga8 ll. 1069-1086) In the context of terminal care for cancer patients, MS patients principally thought of palliative care as a positive approach.
Models of MB function have inevitably focused on their dense hippocampal inputs (Aggleton and Brown, 1999) so that the MBs are principally thought to relay hippocampal information to the anterior thalamic nuclei (via the mammillothalamic tract), and then beyond (e.g., Barbizet, 1963; Delay and Brion, 1969).
The deputy prime minister argued there was an assumption on the centre-left that austerity measures were, by definition, regressive and rightwing: "And I think principally the reason is because collective memory of difficult budget decisions harks back to the 1980s, the harshness of the 1980s, north-south divide, sink-or-swim economics..".
Erdogan told me that the poem had been approved for textbooks by the education ministry, and he added, somewhat disingenuously, I think, that it principally served oratorical purposes.
