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Subsequently, doses were grouped according to cumulative and peak exposures and five different treatment groups were defined: placebo, low dose (0.03 mg/kg i.v. once), intermediate doses (0.1 and 0.3 mg/kg i.v. once, 5 and 15 mg s.c. monthly), medium doses (1.5 mg/kg i.v. once, 50 mg s.c. monthly and 150 mg s.c. once) and high doses (10 mg/kg i.v. once and 150 mg s.c. monthly).
Canakinumab groups were categorised as low (0.03 mg/kg i.v. once; N = 20), intermediate (0.1 and 0.3 mg/kg i.v. once, 5 and 15 mg s.c. monthly; N = 247), medium (1.5 mg/kg i.v. once, 50 mg s.c. monthly and 150 mg s.c. once; N = 268), and high doses (10 mg/kg i.v. once and 150 mg s.c. monthly; N = 137) and compared with placebo (N = 354).
monthly; medium dose: 1.5 mg/kg i.v. once, 50 mg s.c.
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"I once heard 36 Polish pipes and 8 Polish violins playing together," he added.
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I once spent 10 minutes watching dozens of vehicles go past.
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