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We have shown that standard F genomes consistently possess a "full length" F-ORF-VD1 (with one exception that could represent a sequencing error), suggesting the hypothesis that a "full length" F-ORF-VD1 is (i) necessary for maternal transmission and/or (ii) its presence could interfere with male transmission.
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References: Paolicelli, RC et al (2011) Synaptic Pruning by Microglia Is Necessary for Normal Brain Development.
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RSD-NO's ACT Results: Nowhere Near What Is Necessary for Guaranteed, Four-Year-College Admission" at deutsch29.wordpress.com.
Chai, Z., et al., "Interleukin (IL -6 Gene ExpressIL -6n the Central Nervous System Is Necessary for Fever Response to Lipopolysaccharide or IL-1 Beta: A Study on IL-6-Deficient Mice," Journal of Experimental Medicine 183 (January 1996): 311-316.
Dear Adviser: Is it necessary for a company to have a business plan, or offices?
Is it necessary for a casual user to know this much detail?
Second, emergency vehicles: Is it necessary for all sirens blaring on every response by the police, firefighters and paramedics?
Is it necessary for there to be a public debate about the merits of infants' sleeping with their parents?
Is it necessary for Clara to have to grapple with the ageing of Matt Smith into Peter Capaldi when the Time Lord is about 2,000 years old anyway?
Is it necessary for soldiers to be abused and tortured by their fellow troops in order for the military to be strong?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com