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In practical calculation, considering the error of covariance matrix, the N roots z ^ i nearest to the unit circle can be estimated as the DOAs of the signals.
(i) Nearest TSS: the region between the upstream and downstream midpoints of a gene's TSS and the adjacent gene's TSS, equivalent to assigning each peak to the gene with the nearest TSS.
(i) Nearest gene: the region from the midpoint between the TSS and the adjacent gene's TSS or TES (whichever is closest) to the midpoint between the TES and the adjacent gene's TSS or TES (whichever is closest).
But diffusion and active transport mechanisms that might carry emissions from the focus typically result in higher exposures near the focus, and it thus may make sense to use a maximum distance within which k i nearest neighbors are found.
The clustering coefficient is defined as C i = 2 n/ k i (k i – 1), where n is the number of direct links connecting the k i nearest neighbors of node i.
Clustering coefficient (C Clu) is defined as where n denotes the number of direct links connecting the K i nearest neighbors of node i. C Clu ranges from zero (for a node that is part of a loosely connected group) to one (for a node at the center of a fully connected cluster).
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Al Green, "The End Is Near" (1989).
(See "Bernanke: The End Is Near". ).
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CEO of Professional Science Editing for Scientists @ prosciediting.com