Sentence examples for I modification in from inspiring English sources

The hydroxyl group reaction center added via Phase I modification in 4-hydroxy-PCB3 (Fig.  6, PCBI2) generates 4-PCB3-sulfate (PCBII3) and 4-PCB3-glucuronide (PCBII4).

In addition to these so-called 'recoding' editing events, many pre-mRNAs undergo A-to-I modification in untranslated exonic, and in non-coding intronic sequences.

Notably, paromomycin treatment leads to a significant reduction in mcmU, as well as to an increase in mC and I modifications, in SW620-LacZ expressing cells, relative to untreated cells.

Estimated GFR was calculated using a validated online equation provided by K/DOQI (Modification of Diet in Renal Disease (MDRD) study group and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) group; http://www.kidney.org/professionals/kdoqi/gfr_calculator.cfm).org/professionals/kdoqi/gfr_calculator.cfm

Possible reasons for this unexpected finding are: i) a modification in the 3D structure of the channel subunit during a preparation step relocating the S1 S2 domain to the intracellular face of the membrane; or ii) the predicted transmembrane topology of the channel subunit does not correspond to its real conformation in vivo.

An additional factor to consider is that formation of the conjugation products depends on Phase I modification, as the atoms introduced in this step form the reaction centers for Phase II conjugation.

With such sample, the transitional mechanism from form II to form I modification is further investigated by in situ WAXD combined with FTIR spectroscopy.

Cytochrome P450 (CYP) enzymes play an especially important role in Phase I modification, which often involves oxidizing the substrate by introducing a hydroxyl group or oxygen atom.

By contrast, bigger spheres had incorporated no or rare GFP+ cells, only at the periphery, which demonstrated remodelling of tumour fragments (i.e., modification in cell cell interaction) seems to occur only in surface of colosphere.

Our hypotheses provide an opportunity to understand the regulatory mechanisms involved in O-GlcNAc modification of proteins and will be helpful in answering some of the unanswered questions in this field such as: i) Why O-GlcNAc modification in proteins is so intimately associated with phosphorylation?

In class I modifications, the saddle was designed as 10 mm mesiodistally, 2.5 mm buccally, and 2.5 mm lingually from the center of the implant (Fig. 2).