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However, the complex situation, with protein bound circulating IGF-I and locally produced IGF-I, makes it difficult to demonstrate defined roles for the various IGF-I compartments, particularly when binding proteins themselves may have independent regulatory functions across muscle membranes [ 11, 12].
When I see that it makes it difficult for me to come to those spaces as well.
"I'm going to just try to play the best I can play, and if it makes it difficult on them to make a decision, great.
"I made it difficult for the team to follow me at times," he says.
I made it difficult for Phil to get his momentum going".
I made it difficult for people – including my mother – to get close to me, but we're now closer than ever and see each other several times a week.
I made it difficult for him to do anything.
"I'm happy with how I adjusted to conditions, I made it difficult for him to win free points.
Other comments regarding design included the absence of a tab on Cannula P's catheter compared with Cannula I, making it difficult to advance.
"And when I didn't, it made it difficult to get it back".
The unparalleled complexity of the nonhuman primate MHC class I region makes it difficult to describe simply the full diversity of class I alleles expressed by an animal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com