Exact(16)
This machinery is related to the eukaryotic ESCRT-III machinery which, while best known for its role in cell sorting, also has been seen to fulfill a role in separation between divided cell, suggesting an ancestral role in cell division.
The fibrillar centre (FC) is enriched in components of the RNA pol I machinery.
Further, Type I machinery was speculated to play an important role in this aPDT procedure.
Post-translational modifications of the RNA pol I machinery are required for the formation of a productive preinitiation complex.
This re-directed trafficking/delivery of LMP2A to the MHC class I machinery enhances recognition and killing by LMP2A-specific CTL in vitro.
The phosphorylation status of several components of the RNA pol I machinery can modify the activity and interactions of these proteins and thus can modulate rDNA transcription during the cell cycle.
Similar(44)
T. brucei has also co-opted the Pol-I machinery for VSG expression, leading to the formation of a novel extranucleolar, telomere-associated Pol-I compartment.
Next we partitioned the genes according to functional category: (i) flagellar machinery (7973 codons), (ii) non-flagellar functions (1427 codons) and (iii) unknown functions (2308 codons).
This tight link between RNA-polymerase I (Pol I) activity, nucleolar integrity and p53-mediated damage control has also been observed after genetic inactivation of the Pol I-specific transcription initiation factor IA (TIF-IA), placing the Pol I transcription machinery in the centre of control pathways that are influenced by p53.
Previous studies have demonstrated that viruses have evolved mechanisms to inhibit MHC class I expression by interfering with the function of the MHC class I assembly machinery in the endoplasmic reticulum and by exploiting endoplasmic-reticulum-associated degradation pathways [ 38].
Several different mechanisms have been described that influence the class I presentation machinery [ 67], leading to down regulation or loss of HLA class I on the cell surface [ 9, 53].
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