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Based on this hypothesis, one would expect that (i) lowering of Zn2+ concentrations in parallel with Shank1 depletion should lead to a drastic reduction of PSDs in mature synapses and (ii) overexpression of the synaptic Shank1 and PSD-95/GKAP at early stages of synaptogenesis should stabilize PSDs.
Why am I lowering taxes on the middle-class?
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Is lowering LDL, the "bad" cholesterol, all that counts?
I lowered my voice.
I lowered the budget.
Finally, I lowered the glass.
I lower the rifle".
I lowered taxes".
"I lowered assessments".
I lowered my goggles.
I lowered my spoon.
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