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When expressed in cultured hippocampal neurons, the resulting fusion protein ChR2-YFP-NavII-III localised extremely well to the AIS (Figure 1A, top), unlike ChR2-YFP (Figure 1A, bottom).
Stage at diagnosis was determined using the cancer registry and/or FIGO stage information from each site (SEER guidelines: http://seer.cancer.gov/) and categorised as FIGO stage I/II (localised and regional) and FIGO stage III/IV (distant).
The stage of breast tumour is coded as I (localised cancer), II (regional cancer), III (cancer fixed to the skin or the chest wall), or IV (cancer with distant metastases).
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While both reports observe condensin I at chromosome ends during diplotene, we also observe condensin I localising to chromosomal axes as early as zygotene.
The consensus map developed in this study was used to (i) localise QTLs and major genes that were identified in the six DH populations; and (ii) identify chromosomal rearrangements such as duplications and inversions on the basis of markers.
Participants were included if diagnosed with plantar heel pain described as (i) a localised pain at the plantar heel; (ii) that was worst when first standing or walking after rest; and (iii) that improved initially after first standing but worsened with increasing activity.
Quantitative assessment of tumour and measurable normal tissue uptake of antibody by SPECT at each imaging time is shown in Figure 4. I-hDFM localised to the tumour within 2 h of injection (median 4.0% i.a. kg−1) and tumour uptake reached a maximum median level of 4.1% i.a.a
I-hDFM localised to 11 out of 14 of the known sites of tumour recurrence in eight patients known to have metastatic disease by standard radiological techniques.
Individuals were assigned one of three scores: 1=localised (i.e., localised and indolent), 2=intermediate (i.e., generalised indolent/localised aggressive), 3=disseminated (i.e., generalised and aggressive).
Low-risk birth units can either be freestanding, i.e. localised away from a hospital, or sit alongside, i.e. integrated within a hospital.
"There's something the matter with me I dont know what it is … I have a curious aching … I cant localise it … It unsettles me completely," he tells the eldest, most sensible of the physicians, Sir Patrick Cullen, who, knowing there is nothing so disturbing as an ill doctor, recognises that he is about to make a fool of himself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com